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eQTL lookups in GTEx V7 (13 Brain tissues with 80 samples) [39], Brain xQTL [40] and BRAINEAC [41] databases revealed that the A allele at rs462779, which decreases risk of smoking initiation, also decreased expression of REV3L in cerebellum in GTEx (A allele P = 4.8x10 -8

Despite these efforts, research has demonstrated the PNE in any form has the potential to result in deleterious outcomes such as placental abruption, preterm birth, low birth weight and fetal growth restriction, stillbirth, and sudden infant death syndrome [ In conclusion, the results of this review suggest the importance of ceasing smoking and any form of nicotine exposure during pregnancy to mitigate the risk of long-lasting complications on offspring

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