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With this study, we have found that people who smoke a pack a day develop an average of 150 extra mutations in their lungs every year, which explains why smokers have such a higher risk of developing lung cancer. Additionally, other organs were also affected and the study showed that a pack a day led to an estimated average 97 mutations in each cell in the larynx, 39 mutations for the pharynx, 23 mutations for the mouth, 18 mutations for the bladder, and 6 mutations in every cell of the liver each year

This means that in the same study, one can evaluate lung inflammation (BALF analysis, gene and protein expression analysis, histopathology), emphysematous changes (histopathology), lung function, and lung carcinogenesis (histopathology) together with carcinogen exposure (biomarkers of exposure, metabolic responses to carcinogen exposure [gene and protein expression]) and the response to DNA damage based on gene expression data

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Not all individuals are equally exposed to the blood sugar-raising effects of nicotine