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It is clinically relevant to have the knowledge of these interactions, as certain medication can lower clozapine level (thereby causing relapse & worsening of schizophrenia symptoms) or increase clozapine level (thereby causing toxicity and increasing clozapines side effects) Lets begin by discussing this hypothetical case: Q: A 23-year-old man was admitted to the inpatient psychiatry unit after a suicide attempt 3 weeks ago

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The carcinogens of tobacco smoke are thought to cause direct and indirect DNA mutations, and indirect DNA damage which disturbs the cellular processes 22 and switches tumor suppressor genes or oncogenes, on or off, and related to the development of OSCC 26

Also, it appears that passive smoking exposure doesnt have an effect on UC development or symptoms in adults