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Studies have reported that approximately a quarter of e-cigarette users are first-generation users while about three quarters of users use advanced devices, including modified devices [5, 7, 8]

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An explosion of investigations led to the discovery that endogenous prostaglandins are involved in cytoprotection via putative mechanisms which includes mucus secretion, release of bicarbonate, maintenance and strengthening of mucosal blood flow and free radical scavenging [15, 16, 17, 18]

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