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J Ophthalmol

The average pack of cigarettes costs $8.00

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Acrolein as an electrophile can induce the activation of Nrf2 independently of NADPH oxidase, by depletion of GSH [32], by limiting the enzymatic activity of thioredoxin, peroxiredoxins and other Nrf2 transcription targets, through adduct formation [70] and by potentially reacting with KEAP1 cysteine residues, promoting Nrf2-KEAP1 dissociation [31] [4]