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The researchers admit that their calculation is crude as it relies on averages, assumes the health effects of smoking are evenly spread throughout a smoker's lifetime and they are using that the number of cigarettes smoked throughout a lifetime is constant

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Together with the more robust inflammatory response we observed to a viral challenge, this may explain why viral infections tend to be more severe in smokers 51 and may serve as a caution when treating lung cancer patients with oncolytic viral therapy