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Phenylethylamine and benzaldehyde in cigarette smoke were reported to reduce the activity of CYP2A6 ( For total cigarette smoke composition, numerous studies have shown that cigarette smoke extracts (CSE) were more addictive than nicotine alone at the same concentration ( Conditioned place preference (CPP) is a classical method in drug reinforcement research (Venton and Cao, 2020), and the biosensor also responded well to DA in both rodents and neurons in vitro ( In the present study, we used the CSE of denicotinized cigarettes (made of cut tobacco after chemical extraction) as a model for non-nicotine constituents

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