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We configured the upper limit of joinpoints at five, which provided an adequate level of flexibility for trend detection without leading to overfitting of the model

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After adjusting for these variables, e-cigarette users were 34 percent more likely to have a heart attack, 25 percent more likely to have coronary artery disease and 55 percent more likely to suffer from depression or anxiety

The study protocol was approved by the Ethics Committee of Beijing Huilongguan Hospital, and written informed consent was obtained from all patients