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Five Topmost Addictive Substances in the World Commonly Used Drugs Tobacco Nicotine StoryMD Most tobacco products, including e cigarettes, contain nicotine, a chemical that can harm the heart, brain and whole body. As with other addictive products, using a nicotine product builds tolerance, leading to more What is nicotine and other facts PMI Philip Morris International Tobacco : Behind the Smoke (infographic)
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