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This is produced by an open- or closed-system electric heating element that activates when the user inhales air through the device ( Aerosol of PG/VG (50%/50%) in vitro models increased the expression of inflammatory markers (IL-6, IL-8, and MMP-9) and mucins (MUC5AC and MUC5B) ( C57BL/6J mice exposure to PG/VG increased the levels of inflammatory cytokines (keratinocyte chemoattractant, IL-6, and monocyte chemoattractant protein-1) in bronchoalveolar lavage fluid (BALF), suggesting lung damage ( The addition of flavors to e-cigarettes has resulted in adolescents and young adults being the primary consumers of these electronic devices ( Caucasian adolescents and young adults using fruity, mint, or menthol-flavored e-liquids with high nicotine concentrations (5%) have shown higher dependence, increased vaping frequency, and lower intentions to quit, suggesting a dose-response relationship between nicotine strength and addiction ( Those who favor these flavors also tend to use them more frequently (18.71 days vs

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Public health campaigns emphasize cessation over switching, with nicotine replacement therapies offering safer alternatives