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The Deutsche Tabakgegner (German Tobacco Opponents) was published in Dresden from 1919 to 1935, and was the second journal on this issue

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In the mid-20th century, medical research demonstrated severe negative health effects of tobacco smoking such as lung cancer, which led to governments adopting policies to force a sharp decline in tobacco use

Biomedical studies were slow to provide evidence because laboratory animals could not be persuaded or forced to smoke cigarettes, but eventually they yielded valuable information on the role of tobacco in the causation of cancer and heart disease