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Sample size determination The sample size for the study has been calculated based on the volume of smoke inhaled by participants, which is one of the primary outcome measures

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Nicholson conceded Lorillards belief that asbestos must be eliminated from the Kent cigarette as soon as possible, although his memo absurdly blamed a whispering campaign started by their competitors of the harmful effects of asbestos. Therefore, H&V would discontinue that part of our research program devoted to the fixing of asbestos fibres and direct the entire attention of the program toward the complete elimination of asbestos. Despite the consensus reached among its researchers and those of H&V, Lorillard said nothing publicly about the risks of Micronite filters, kept using asbestos in them for another 16 months, and continued to sell existing stocks of Kents for several more months after that