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They were a superior alternative to normal cigarettes, one 1940 ad argued, in part because of their greater safety. The companys menthol cigarettes, called Spuds, became the fifth-best-selling cigarette brand in the country seven years after they hit the market

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After nicotine exposure, KCC2 fails to maintain the established Cl- gradient, and the progressive decrease in the evoked IPSC amplitudes (Fig 2E, red data) indicates Cl- accumulation inside the cell