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Genetic differences in the enzymes processing nicotine affect the speed at which the enzyme works, and reduced blood flow to the liver as you age may account for the slower processing of nicotine

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Arterioscler Thromb Vasc Biol 34(3):509515 Mulsch A et al (2001) Effects of in vivo nitroglycerin treatment on activity and expression of the guanylyl cyclase and cGMP-dependent protein kinase and their downstream target vasodilator-stimulated phosphoprotein in aorta

18 more per 1000, 95% CI 1 to 41 more), and tailored (10 RCTs, n = 14 259