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It can contain harmful and potentially harmful substances, including nicotine, heavy metals like lead, volatile organic compounds, and cancer-causing agents." Sadly, it counts as an improvement that the CDC is willing to explicitly say e-cigarettes are less harmful than regular cigarettes instead of dodging the question entirely

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71,108,109 Validation of tobacco exposure biomarkers is threefold: method validation, validation with respect to product use, and validation with respect to disease risk

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Scott Gottlieb, the agencys commissioner, in a Friday announcement, where he laid out an intention to focus the agency on reducing the harm nicotine causes society