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The finding that cocaine self-administration in adolescents is mediated by D 2 receptors is in marked contrast to adults, where D 1 receptors mediate cocaine reinforcement (59)

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Participants younger than 60 years (n = 285,022), without ethnic background information (n = 1182) or not White British (n = 17,400), with missing APOE genotype information (n = 5324) or 1 allele (n = 25), with unmatched self-reported sex and genetic sex (n = 121) and excessive relatives (n = 88), and with dementia at baseline or prior to recruitment (n = 145) were excluded (Supplementary Fig