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This is due to nicotine, the addictive ingredient in tobacco

The meta-analytic tool overcomes many of the limitations of traditional meta-analyses by incorporating between-study heterogeneity into the uncertainty of risk estimates, accounting for small numbers of studies, relaxing the assumption of log(linearity) applied to the risk functions, handling differences in exposure ranges between comparison groups, and systematically testing and adjusting for bias due to study designs and characteristics

This can lead to lung problems and respiratory diseases like a persistent cough, chest pain, and cancer

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Pod systems might suit light smokers or those prioritizing simplicity, while heavy smokers might benefit from the power of box mods