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Strong recommendations are typically based on high-certainty evidence (i.e., high confidence in the estimate of the effect of an intervention) and may recommend in favour of an intervention (when there is high confidence of net benefit) or against an intervention (when there is high confidence of net harm)

INTRODUCTION Nicotine, present in tobacco leaves, and alcohol consumption are both known to cause addiction

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Product Types and User Preference Disposable Vapes : More popular in black market-heavy regions, with (54%) of users in Brazil and (37%) in Mexico opting for disposable vapes

Cigarette consumption attributable to purchases made on Indian reservations We estimated the percentage of cigarette consumption from Indian reservations by state by dividing the cigarette consumption purchased from Indian reservations by the annual total cigarette consumption in that state