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When cells become damaged and are replaced their DNA/RNA degrade into purine molecules which are then metabolized into uric acid

In vitro studies have shown that Ang II stimulates superoxide anion production in mesangial cells (Jaimes et al., 1998), whereas OxS was shown to be a direct stimulator of AT1R expression in an animal study ( 3.3 OxS and insulin Increased ROS production and OxS caused insulin resistance in vitro and in animal studies (Fazakerley et al., 2018)