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Because the brain is still developing well into the mid-20s, adolescents can become addicted to nicotine more easily than adults

One which would follow subjects for extended time periods to better track changes and establish causation

Conversely, adjusting for gender and exact age at scanning, but looking instead at rate of thinning in current smokers (to avoid confounding this rate by the effect of recovery that is observed in ex-smokers), revealed, within areas of pack-years-associated cortical thinning, that mean cortical thickness was 3.21 m thinner for every pack-year smoked (95% confidence interval, 5.82 to 0.60 m

The vast majority of the deaths before 2050 will occur among current smokers

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