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Patients with Left Ventricular Dysfunction: During a chronic dosing trial with bupropion in 14 depressed subjects with left ventricular dysfunction (history of CHF or an enlarged heart on xray), there was no apparent effect on the pharmacokinetics of bupropion or its metabolites, compared with healthy volunteers

Overall, various murine models of inflammatory arthritis represent the opportunity to investigate the effect of environmental factors, such as CS, on the development, progression, and response to therapeutics