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It should not be used in patients with active peptic ulcer, severe renal failure, or severe liver disease

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(7) In May of 2018, the Drug Enforcement Administration (DEA) stated, "Fentanyl is the most prevalent and the most significant synthetic opioid threat to the United States." In 2024, the DEA seized more than 55,000,000 fentanyl pills and almost 4 tons of fentanyl powder enough to kill 367,000,000 people.(8) Illegally made fentanyl may be mixed with other drugs, that change the properties of fentanyl, or the experience of the individual exposed to it