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Scoring and estimation of measures : To facilitate appropriate use of the ABOUT-Dependence measure, a calibrated scoring scheme was developed to enable conversion of unweighted sum scores into linear measures based on weighted likelihood estimation (WLE) 58 , and the calibration was done with the unrestricted Rasch model for polytomous responses 59,60

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In addition to these direct DNA mutations, many carcinogenic chemicals in tobacco cause DNA to behave abnormally

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