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In the brain, nicotine works mostly to release other neurotransmitterslike dopamine (pleasure), norepinephrine (arousal and appetite suppression), glutamate (learning and memory), endogenous opiates, and serotonin (mood modulation)

However, as cannabis use becomes increasingly widespread due to legalization and social acceptance, concerns have arisen regarding its potential role in respiratory pathology and carcinogenesis (5)

However, consumption of raw hemp is neither pleasant, nor advisable to get the level of CBD necessary to elicit a biological and potentially therapeutic or medicinal response

PMID 26650455

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