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When nicotine is inhaled or absorbed through the skin, it rapidly reaches the brain, where it binds to nicotine receptors and triggers the release of dopamine, a neurotransmitter associated with pleasure and reward

In other terms, when compared with people who dont smoke, women who smoke about one cigarette per day have a 57% higher risk of heart disease and a 31% higher risk of for stroke (or 119% and 46% when allowing for multiple confounders)

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