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In contrast, our MR analysis employed SNPs as IVs to mitigate these biases and yielded more accurate estimates of potential causality, leveraging a much larger GWAS sample of European ancestry (COPD, n=468475)

Chronic bronchitis is a more persistent condition and is classified under chronic obstructive pulmonary disease (COPD)

Eighty per cent of the worlds smokers live in low and middle-income countries (LMIC), least able to cope with the disease burden of smoking, and in higher income countries, smoking is a major cause of health inequalities