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Given that the elevated ILC3 frequencies in smokers with asthma correlated positively with not only smoking amount and decreased lung function but also M1 macrophage and circulating neutrophil frequencies, it may be the key player in the pathogenesis of smoking-related asthma is the ILC3s

Of the 17 studies, 15 recorded smoking as a binary yes or no, while 2 studies reported the number of cigarettes smoked during pregnancy

In consequence, a collateral enrichment of the heterotrophic Gammaproteobacteria, and like any other Proteobacteria, is Gram-negative

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