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They found that when governments put small, incremental tax rises on the cost of tobacco and when Roll-Your-Own tobacco is taxed at a lower rate than factory made cigarettes, smokers shift from factory made to Roll-Your-Own and roll thinner cigarettes to keep their addiction affordable rather than quitting

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At the cellular level, the possible mechanism of this detrimental outcome in mice that were switched to IQOS inhalation could be due to impaired phagocytosis, thereby leading to the persistence of NTHI bacteria in the lung as has been demonstrated in the case of cigarette smoke [9, 19, 29, 30]