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Additionally, there may be important differences between adolescents and adults especially in terms of whether or not they have already developed nicotine dependence, and therefore whether e-cigarettes represent a quitting aid or a possible gateway drug 44

Yet another embodiment of the invention, wherein the mainstream smoke solution is incapable of producing significant oxidative damage to guinea pig lung microsomal proteins in vitro One more embodiment of the invention related to use of nicotine fortified tobacco, which results in increase in delivery of nicotine without increasing the level of p-BSQ

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