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Data availability The datasets used and/or analysed during the current study available from the corresponding author on reasonable request

The toxic threshold for nicotine in adults is approximately 0.5-1mg per kg of body weight

The incidence rates for infectious diseases (LRTIs, GIs, URTIs, non-focal viral infections and miscellaneous infections) and non-infectious diseases were calculated as the number of events divided by the number of PYO, adjusting for clustering by multiple episodes in an individual

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Tobacco or nicotine addiction treatment is like recovery from any other addictive substance