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The relative deactivations observed in orbitofrontal cortex (generally recognised as an area that responds to olfactory stimuli 36 ) may therefore be a result of the less powerful olfactory properties of ENDS, and this area (plus other olfactory areas such as the piriform cortex) may respond more strongly to tobacco cigarette smoking

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Zelikoff JT, Parmalee NL, Corbett K, Gordon T, Klein CB, Aschner M (2018) microglia activation and gene expression alteration of neurotrophins in the hippocampus following early-life exposure to E-cigarette aerosols in a murine model

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