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More importantly, in the present study, all participants were exposed to a 60-minute extinction phase yet only those also exposed to the stressor exhibited significant decreases in cigarette use

Key to this approach are (i) the use of agreed reference products for comparison, ideally authorized MRTPs, and (ii) bridging methodologies that allow to compare a cMRTP with the reference products based on a limited number of studies (see challenge 4)

This was a really interesting conversation because it highlighted how many everyday products people interact with regularly without thinking much about the long-term implications

Spearmans ranked test: = 0.976, p = 2E-7, 95% CI = [0.99, 0.87]