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45 b Example interventions are those that demonstrated a positive direction of effect on smoking cessation, were at low risk of bias, and took place in the United States in primary care or a primary careapplicable setting among an unselected sample of adults (ie, those not selected based on having smoking-related disease or other comorbid conditions)

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We extracted genetic data for these specific human blood metabolites (i.e., tryptophan, tyrosine, phenylalanine, glutamate, glycine, and valerate) from a GWAS comprising 7824 European adult individuals [40, 41]

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