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The UK Committee on Toxicity (COT) highlighted significant reductions in levels of harmful and potentially harmful constituents (HPHCs) in the aerosol of HTP compared to cigarette smoke and stated that [t]here would likely be a reduction in risk for conventional smokers deciding to use heat-not-burn tobacco products instead of smoking cigarettes. COT added that [a] reduction in risk would also be experienced by bystanders where smokers switch to heat-not-burn tobacco products

High-nicotine electronic cigarette products: toxicity of JUUL fluids and aerosols correlates strongly with nicotine and some flavor chemical concentrations