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Our study has conclusively demonstrated that cigarette smoke exposure has a profound suppressive effect on the generation of adaptive immune responses to NTHI and suggests the mechanism by which prior cigarette smoke exposure predisposes chronic obstructive pulmonary disease patients to recurrent infections, leading to exacerbations and contributing to mortality

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Johnson N (2001) Tobacco use and oral cancer: a global perspective J Dent Educ 65 (4) 328339 PMID: 11336118 17

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If you drink too much caffeine close to bedtime, you might experience a disturbed sleeping routine or even insomnia