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[20] Randomized controlled trials have provided "high-certainty" evidence that e-cigarettes containing nicotine are more effective than nicotine replacement therapy for discontinuing tobacco smoking, and moderatecertainty evidence that they are more effective than e-cigarettes free of nicotine

Many nevertheless believe there are risks involved with their largely unregulated use, including unknown long-term safety concerns, their possible impact on children and youth, increased nicotine addiction in the population at large, and the renormalization of a smoking culture

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Regarding the cell count differences, there was a macrophage reduction and a neutrophil increase in the RC group

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