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For although the percentage of people who smoke is steadily waning (in wealthy countries), this is more than compensated by global population growth and the increasing popularity of smoking in poorer countries

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The decline in dopamine and serotonin activity during cessation directly contributes to depressed mood, irritability, and poor sleep

For example, someone who smoked two packs per day for 10 years may have a higher risk than someone who smoked one pack per day for 20 years, even though both have 20 pack years