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Surgeon General , CDC , FDA , AMA, World Health Organization , and the National Institute on Drug Abuse , classifies nicotine as the primary addictive compound in tobacco products.[7] Clinical reports have documented patients who, despite never smoking, developed severe dependence on nicotine gum

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While these were introduced as smoke-free alternatives, they still pose health risks since the aerosol produced may contain nicotine, ultrafine particles, and chemicals that could affect respiratory and cardiovascular health

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