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[10] Long-term exposure to nicotine can also result in downregulation of glutamate transporter 1

[29] Smoking has a causative association with a myriad of other types of diseases, such as heart disease, diabetes, stroke and different forms of cancers

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More work is also needed to continue to monitor national trends in differences in tobacco use and nicotine vaping among adults with or without psychiatric conditionsincluding substance use disorderduring the COVID-19 pandemic

They are a testament to the resourcefulness and creativity of the people who made them and provide a unique window into the history of tobacco farming in the United States