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Heated tobacco involves devices like IQOS that heat real tobacco at lower temperatures, releasing a vapor containing nicotine

It can also result in premature death

The candidate genes that play a key role in nicotine addiction include those associated with the dopaminergic neurotransmitter system (e.g., DRD2, DRD3, DRD4), cellular transport system (e.g., SLC1A2, SLC6A4), serotonergic neurotransmitter system (e.g., HTR2A), nicotinic neurotransmitter system (e.g., CHRNA4, CHRNA5, CHRNA3, CHRNA7, CHRNB4), opioidergic activity (e.g., OPRM1), and nicotine metabolism (e.g., CYP2A6) ( Figure 1 nAChRs are primary targets of nicotine, nicotine exerts direct and indirect effects on other receptor systems (e.g., opioid, serotonergic, glutamatergic) that also mediate nicotine-induced behavioral and neural changes in humans

[16] Nicotine deregulates cardiac autonomic function, boosts sympathetic activation, raises heart rate, causes coronary and peripheral vasoconstriction, increases myocardial workload, and stimulates adrenal and neuronal catecholamine release

smokers, but on limited terms