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They found that Exposure to aerosol from HTPs in a designated smoking room under usual conditions is estimated to be tolerable since the lifetime cancer risk is expected to be below a VSD [virtually safe dose] of 10-5 (1/100,000), which is three orders of magnitude lower than that for cigarettes smoked under the same conditions. Research by the Health Service Division of the MHLW, published in the International Journal of Environmental Research and Public Health, compared the concentration of nicotine and particulate matter (PM 2.5 , particles that are 2.5 microns or less in diameter) in the air following 50 puffs from HTPs or cigarettes in a small, unventilated space (a shower cubicle)

Then, the proportions of combined use of products were calculated, which made the comparison of combined use easier

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In anogenital areas, these include: Red, thin skin Burning discomfort Periorificial dermatitis Candida albicans infection (eg, vulvovaginal thrush) It is most important to follow instructions carefully and to attend follow-up appointments regularly

For this reason, several other synthetic alternatives are available