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From 1998 to 2004, the amount of nicotine in cigarettes increased by an average of 10 percent, according to a 2006 study by the Massachusetts Department of Public Health, though its not clear why or even if such an increase makes cigarettes more addictive

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Analytes were eluted with a mixture of dH 2 O:isopropyl alcohol (85:15) +0.1% FA (125 L) followed by LC-MS analysis via a Shimadzu Nexera XR UPLC coupled with a Shimadzu 8050 triple quadrupole mass spectrometer