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Many nicotine-dependent individuals have comorbid psychiatric disorders, such as attention-deficit hyperactivity disorder (ADHD), anxiety disorders, and depression.[3] Nicotine Dependence & Comorbid Psychiatric Disorders Smoking is the leading and most preventable cause of death in the United States, which is disproportionately affecting those with psychiatric disorders

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and 2) The impact on human health included clinical studies assessing biomarkers of exposure and biomarkers of health effects