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This side effect could be caused by: How the drugs affect taste receptors in the brain The taste of the medication when it's mixed with saliva A drug molecule in a blood vessel of the tongue interacting with taste bud receptors Some of the more common medications that can cause a sour taste in your mouth include: Antibiotics: Including ampicillin, macrolides, quinolones, sulfamethoxazole, trimethoprim, tetracycline, and metronidazole Heart medications: Including many high blood pressure medications, diuretics, statins, and antiarrhythmics Chemotherapy drugs: Including cisplatin, cyclophosphamide, and etoposide Neurologic medications: Including antiparkinson drugs, migraine medications, and muscle relaxants Psychotropic drugs: Including most tricyclic antidepressants, some antipsychotics, anti-anxiety drugs, mood stabilizers, and hypnotics Other prescription and over-the-counter (OTC) drugs: Including thyroid drugs, antihistamines, bronchodilators, anti-inflammatories, smoking cessation aids, antifungals, and antivirals Sour Taste During Cancer Treatment When to Call a Healthcare Provider Treating a sour taste in your mouth depends on whats causing it