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it requires targeted agents to actively signal and promote repair

FDA treated it as 14 questions, not 7

Single-cell RNA sequencing data revealed that M2 macrophages further promote fibrotic processes in PDGFR + DPP4 + fibroblasts through the GAS6AXL pathway ( 5.2 Macrophages and adipocytes: cross-regulatory network between metabolism and immunity The bidirectional interaction between macrophages and orbital adipocytes serves as a pivotal hub regulating orbital tissue volume and inflammatory status