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23 When the emissions of filter ventilated cigarettes are tested in smoking machines under standardised puffing conditions, the amounts of tar, nicotine, carbon monoxide and other chemicals are systematically underestimated, as the puffing conditions do not take into account compensatory smoking modifications (see Section 12.5.2)

Other clinical trials testing the efficacy of e-cigarettes for smoking cessation are ongoing, but existing data are far too sparse to recommend e-cigarettes as a first- or even second-line medication for smoking cessation