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For all models, visual inspection of Q-Q plots prompted concerns of violation of normality of residuals, so each model was bootstrapped 2000 times

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The relatively stable co-use trends may reflect substitution dynamics whereby some individuals replace cigarettes with cannabis, preventing co-use from rising in tandem with cannabis-only use. Other researchers have also separately observed a similar trend where cannabis is increasingly used as an alcohol substitute

Lung cancer deaths averted and person-years of life gained between 1970 and 2022 served as primary endpoints