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This segment's leadership is attributable to the deep integration of nicotine replacement therapy products into national healthcare systems across North America, Western Europe, and Australia, where patches, gums, and lozenges are prescribed or recommended as first-line cessation aids

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Cadmium can contribute to cancer, cardiovascular disease, and osteoporosis

American Economic Review

Creating a satisfying experience without nicotine, tobacco, or smoke meant carefully recreating the sensory details and familiar ritualnot simply taking nicotine away