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Half of studied acute craving episodes lead to lapse within 11 minutes 35 Nicorette Quickmist Mouthspray is clinically proven to start relieving cravings in 30s 11 A maximum concentration of 5.3 ng/mL is reached within 13 minutes after administration of a 2 mg dose 36 Nicorette : faster-acting formats: relieve sudden cravings whenever they strike Faster-acting Nicorette formats such as: QuickMist Mouthspray, Gum, Lozenge, Inhalator or Nasal Spray are absorbed by the oral or nasal mucosa 7 Can be used to prevent and/or relieve sudden cravings when they strike 5 Cytisine: Indicated for reduction of nicotine cravings in smokers who are willing to stop smoking 18 Varenicline: Indicated to help relieve the craving and withdrawal symptoms associated with stopping smoking 19 To keep in mind: With NRT your patients can get craving relief when they strike 7 Support your patient by asking whether they smoke, and recommend stop smoking medication like Nicorette Combination Therapy Nicorette Combination Therapy: Combining two formats for Nicorette Combination Therapy can help to manage nicotine withdrawal symptoms with a long acting patch and a flexible format for cue induced or breakthrough cravings Patch relieves smoking cravings discreetly and continuously over 16 hours 37 , and doesn't add to sleep disturbance Mouthspray starts to relieve withdrawal symptoms in just 30 seconds 11 Nicorette Combination Therapy options 11,37-42 Slama KJ et al

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Stikeman Elliott LLP is acting as legal counsel to Hempshire in respect of the Transaction and Private Placement and will act as counsel to the Resulting Issuer upon completion of the Transaction

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