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Inclusion criteria were: 1) aged 1839 years (21 in Boston due to minimum age of purchase laws), 2) smoke 5 factory-made filtered cigarettes/day for 1 year, 3) fair or better self-rated physical and mental health, and 4) English-speaking

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The same systematic review found oral CBD bioavailability to be very low (reported as 13 to 19% in animal model studies), owing to first-pass hepatic metabolism